PfRH5-PfCyRPA-PfRIPR complex from Plasmodium falciparum bound to antibody Cy.003
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8cdd
Q-score: 0.425
Farrell B, Alam N, Hart MN, Jamwal A, Ragotte RJ, Walters-Morgan H, Draper SJ, Knuepfer E, Higgins MK
Nature (2024) 625 pp. 578-584 [ DOI: doi:10.1038/s41586-023-06856-1 Pubmed: 38123677 ]
- Cysteine-rich protective antigen (40 kDa, Protein from Plasmodium falciparum 3D7)
- Pfrh5-pfcyrpa-pfripr complex bound to fab fragment from antibody cy.003 (Complex from Plasmodium falciparum 3D7)
- Cy.003 light chain (22 kDa, Protein from Gallus gallus)
- Rh5-interacting protein (124 kDa, Protein from Plasmodium falciparum 3D7)
- Reticulocyte-binding protein homolog 5 (60 kDa, Protein from Plasmodium falciparum 3D7)
- Cy.003 heavy chain (23 kDa, Protein from Gallus gallus)
PfCyRPA-PfRIPR complex from Plasmodium falciparum bound to antibody Cy.003
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8cde
Q-score: 0.409
Farrell B, Alam N, Hart MN, Jamwal A, Ragotte RJ, Walters-Morgan H, Draper SJ, Knuepfer E, Higgins MK
Nature (2024) 625 pp. 578-584 [ DOI: doi:10.1038/s41586-023-06856-1 Pubmed: 38123677 ]
- Cy.003 light chain (22 kDa, Protein from Gallus gallus)
- Rh5-interacting protein (124 kDa, Protein from Plasmodium falciparum 3D7)
- Cysteine-rich protective antigen (40 kDa, Protein from Plasmodium falciparum 3D7)
- Pfcyrpa-pfripr complex bound to fab fragment from antibody cy.003 (Complex from Plasmodium falciparum 3D7)
- Cy.003 (23 kDa, Protein from Gallus gallus)
Farrell B, Alam N, Hart MN, Jamwal A, Ragotte RJ, Walters-Morgan H, Draper SJ, Knuepfer E, Higgins MK
Nature (2024) 625 pp. 578-584 [ DOI: doi:10.1038/s41586-023-06856-1 Pubmed: 38123677 ]
PfCyRPA-PfRIPR complex from Plasmodium falciparum bound to antibody Cy.003 consensus maps
Farrell B, Alam N, Hart MN, Jamwal A, Ragotte RJ, Walters-Morgan H, Draper SJ, Knuepfer E, Higgins MK
Nature (2024) 625 pp. 578-584 [ DOI: doi:10.1038/s41586-023-06856-1 Pubmed: 38123677 ]
PfRH5-PfCyRPA-PfRIPR complex from Plasmodium falciparum bound to antibody Cy.003 - consensus map
Farrell B, Alam N, Hart MN, Jamwal A, Ragotte RJ, Walters-Morgan H, Draper SJ, Knuepfer E, Higgins MK
Nature (2024) 625 pp. 578-584 [ DOI: doi:10.1038/s41586-023-06856-1 Pubmed: 38123677 ]
Farrell B, Alam N, Hart MN, Jamwal A, Ragotte RJ, Walters-Morgan H, Draper SJ, Knuepfer E, Higgins MK
Nature (2024) 625 pp. 578-584 [ DOI: doi:10.1038/s41586-023-06856-1 Pubmed: 38123677 ]
Farrell B, Alam N, Hart MN, Jamwal A, Ragotte RJ, Walters-Morgan H, Draper SJ, Knuepfer E, Higgins MK
Nature (2024) 625 pp. 578-584 [ DOI: doi:10.1038/s41586-023-06856-1 Pubmed: 38123677 ]
Farrell B, Alam N, Hart MN, Jamwal A, Ragotte RJ, Walters-Morgan H, Draper SJ, Knuepfer E, Higgins MK
Nature (2024) 625 pp. 578-584 [ DOI: doi:10.1038/s41586-023-06856-1 Pubmed: 38123677 ]
Structure of PfNT1(Y190A)-GFP in complex with GSK4
Resolution: 4.04 Å
EM Method: Single-particle
Fitted PDBs: 7ydq
Q-score: 0.31
Structure of Plasmodium falciparum 20S proteasome with bound bortezomib
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7lxt
Q-score: 0.498
Xie SC, Metcalfe RD, Mizutani H, Puhalovich T, Hanssen E, Morton CJ, Du Y, Dogovski C, Huang SC, Ciavarri J, Hales P, Griffin RJ, Cohen LH, Chuang BC, Wittlin S, Deni I, Yeo T, Ward KE, Barry DC, Liu B, Gillett DL, Crespo-Fernandez BF, Ottilie S, Mittal N, Churchyard A, Ferguson D, Aguiar ACC, Guido RVC, Baum J, Hanson KK, Winzeler EA, Gamo FJ, Fidock DA, Baud D, Parker MW, Brand S, Dick LR, Griffin MDW, Gould AE, Tilley L
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2107213118 Pubmed: 34548400 ]
- 20s proteasome beta-2 subunit (25 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-2 subunit (26 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- N-[(1r)-1-(dihydroxyboryl)-3-methylbutyl]-n-(pyrazin-2-ylcarbonyl)-l-phenylalaninamide (384 Da, Ligand)
- 20s proteasome alpha-4 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-3 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-5 subunit (23 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-6 subunit (28 kDa, Protein from Plasmodium falciparum)
- 20s proteasome beta-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-6 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-5 subunit (28 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-3 subunit (24 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-4 subunit (22 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- Plasmodium falciparum 20s proteasome complexed with bortezomib (700 kDa, Complex from Plasmodium falciparum 3D7)
- 20s proteasome alpha-7 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-7 subunit (30 kDa, Protein from Plasmodium falciparum (isolate 3D7))